LB809: Dioscorea Extract Targets STAT3 Pathway in Psoriasis Model
LB809, a Dioscorea septemloba Thunb extract, suppressed LYN-mediated STAT3 phosphorylation and exosomal LRG1 exchange in a psoriasis-like model (JID, Oct 2026).
Topic
Keratinocytes
Topic
Keratinocytes
Dantrolene Sodium Restores Mitochondrial Calcium in Darier Disease
A preclinical study in the Journal of Investigative Dermatology shows dantrolene sodium partly restores mitochondrial calcium in…
Single-cell transcriptome maps keratinocyte subclusters in atopic dermatitis
A Nature single-cell transcriptome study identifies keratinocyte subclusters driving altered differentiation and inflammatory res…
IGFL1 and IGFL4 Identified as IL-4/IL-13-Driven Amplifiers in Atopic Dermatitis
A JID study from Indiana University identifies IGFL1 and IGFL4 as IL-4/IL-13–responsive amplifiers in atopic dermatitis, mapping…
Blocking Cellular Recycling Cuts Psoriasis Inflammation
Preclinical evidence links autophagy inhibition to reduced psoriatic inflammation. The cellular recycling pathway emerges as a ca…
Epidermal TLR4 Deletion Shields Mouse Skin From UV Damage and Tumors
Keratinocyte-specific Tlr4 deletion protected SKH-1 mice from UV photodamage and photocarcinogenesis, matching topical resatorvid…